Sponsor Deadline for Letters of Intent (requested but not required): January 1, 2023

FAS/SEAS/OSP Deadline: January 25, 2023

Sponsor Deadline for Full Proposals: February 1, 2023

Award Information: Application budgets are not limited. The maximum project period is 5 years. NIH intends to commit an estimated total of $30M per fiscal year to fund 1-3 Comprehensive Centers.

This FOA intends to support large-scale Comprehensive Center(s) that will adopt high throughput imaging technology platforms to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BRAIN Initiative Cell Atlas Network (BICAN) is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.

Sponsor Deadline for Letters of Intent (requested but not required): January 1, 2023

FAS/SEAS/OSP Deadline: January 25, 2023

Sponsor Deadline for Full Proposals: February 1, 2023

Award Information: Application budgets are not limited. The maximum project period is 5 years. NIH intends to commit an estimated total of $4M per fiscal year to fund 1-3 awards.

This FOA intends to support cloud-based common imaging data processing pipelines to uniformly process high-volume imaging-based brain cell atlas data. The purpose is to visualize, register, analyze, and integrate the cell atlas imaging data, and characterize molecular and anatomical phenotypes and features of brain cells. The overall goals of Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data Findable, Accessible, Interoperable, and Reusable (FAIR), and the process transparent. An application is expected to propose only one of the above four respective elements.

Sponsor Deadline for Letters of Intent (requested but not required): 30 days in advance of the full proposal deadline

FAS/SEAS/OSP Deadline: 5 business days prior to submission

Sponsor Deadlines for Full Proposals: February 1, 2023; February 1, 2024

Award Information: Application budgets are not limited. The maximum project period is 3 years. NIH intends to commit an estimated total of $6M per fiscal year to fund 4-8 Specialized Collaboratories.

This FOA intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, mouse, and other species in coordination and collaboration with other BRAIN Initiative Cell Atlas Network (BICAN) projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.