Sponsor Deadline for Letters of Intent (requested but not required): 30 days in advance of the full proposal deadline
FAS/SEAS/OSP Deadline: 5 business days prior to submission
Sponsor Deadlines for Full Proposals: December 15, 2022; September 12, 2023; September 12, 2024
Award Information: Application budgets are not limited, but are expected to range between $150,000 to $250,000 in direct costs per year. Awards are for three years of support. The NIH BRAIN initiative anticipates providing $6M per year to fund up to 15 awards each year.
This FOA seeks the development of theories, computational models, and analytical tools to derive understanding of brain function from complex neuroscience data. Proposed projects could develop tools to integrate existing theories or formulate new theories; conceptual frameworks to organize or fuse data to infer general principles of brain function; multiscale/multiphysics models to generate new testable hypotheses to design/drive future experiments; new analytical methods to substantiate falsifiable hypotheses about brain function. It is expected that the tools developed under this FOA will be made widely available to the neuroscience research community for their use and modification. Investigative studies should be limited to model parameter estimation and/or validity testing of the tools being developed.
For this reissue, priority will be given to the development of:
- Analytical and computational tools to facilitate new theory development as well as tools to integrate existing (especially competing) theories, and conceptual frameworks
- Multiscale/Multiphysics models incorporating biologically-inspired dynamical representations of neurons mechanistically linking to behavioral processes
- Platforms incorporating machine-driven knowledge integration of competing theories for the discovery of foundational theories of the brain