Sponsor Deadline for Letters of Intent (requested): October 9, 2021

Sponsor Deadline for Full Proposals: November 9, 2021

FAS/SEAS/OSP Deadline: November 2, 2021

Award Information: Application budgets are not limited. The maximum project period is 5 years. NIH intends to commit an estimated total of $95M per year to fund 2-4 Comprehensive Centers and 5-10 Specialized Collaboratories.

This FOA intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BRAIN Initiative Cell Atlas Network (BICAN) is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.

Sponsor Deadline for Letters of Intent (requested): October 9, 2021

Sponsor Deadline for Full Proposals: November 9, 2021

FAS/SEAS/OSP Deadline: November 2, 2021

Award Information: Application budgets are not limited. The maximum project period is 5 years. NIH intends to commit an estimated total of $95M per year to fund 2-4 Comprehensive Centers and 5-10 Specialized Collaboratories.

This FOA intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BRAIN Initiative Cell Atlas Network (BICAN) projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.

Sponsor Deadline for Letters of Intent (requested): October 9, 2021

Sponsor Deadline for Full Proposals: November 9, 2021

FAS/SEAS/OSP Deadline: November 2, 2021

Award Information: Application budgets are not limited. The maximum project period is 5 years. NIH intends to commit an estimated total of $5M per year to fund 4-8 awards.

This FOA intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four elements to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engagement and outreach element to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data Findable, Accessible, Interoperable, and Reusable (FAIR), and the process transparent. An application is expected to propose only one of the above four respective elements.